Sherlock Holmes faces a sinister case risking friends' lives. American Amelia joins, seeking her father after her mother's murder. Despite differences, they solve a conspiracy and her mother's case.

Follows both the professional and personal lives of the firefighters, rescue personnel, and paramedics of the Chicago Fire Department at the fictional Firehouse 51 as they risk their lives to save and protect the city of Chicago, ...

The city's most highly skilled medical team saves lives, while navigating their unique interpersonal relationships.